Melatonin: Separating Fact from Fiction - RD187B

Melatonin: Separating Fact from Fiction

by Summer A. Kramer, PharmD and Daniella Krantz, CPhT, BS, MS
(4.5 / 0 ratings )

This course is credentialed for:
Dietetics/Nutrition (1.00 CPEU)

Price: $20.00
CE-PRO Price: $10.00


Melatonin is a neurohormone produced in the pineal gland and is a regulator of the human circadian rhythm, which is responsible for daily sleep-wake cycles. Melatonin receptors (MT1 and MT2) are located both centrally and peripherally. The physiological effects of melatonin are a result of melatonin receptor activation. In addition to sleep regulation, melatonin has shown potent antioxidant, anti-inflammatory, and anticancer effects in clinical studies. Pharmacologic use of melatonin for various conditions or disorders is fairly common. This course reviews the physiologic and pharmacologic effects of melatonin, including therapeutic benefits and dosing guidelines in various disorders, and highlights areas for future research.


The primary goal of this course is to inform pharmacy personnel of the indications of melatonin in correcting the biological circadian rhythm yet touching on its use as an anti-inflammatory aid and its extended use in Alzheimer’s, autism, and fertility treatments. After studying the information presented here, you will be able to:
  • Discuss the effect of melatonin on the circadian rhythm and other functions of the body.
  • Differentiate patients who may be affected by a clinical sleep disorder vs. a lack of sleep.
  • Identify and counsel patients on non-pharmacologic approaches to sleep disorders or possible contraindications to melatonin use.

Approval Information
This course is intended for an interprofessional audience, including pharmacists, pharmacy technicians, physicians and dietitians.
Dietitians: Take this version of the course to ensure you receive appropriate credit.
For the version accredited or approved for another profession, go to your specific profession at or If you have a CE Direct login ID and password (generally provided by your employer), please log in as you normally would at and search for this topic title.
Jointly Accredited Provider logoIn support of improving patient care, OnCourse Learning (a Relias LLC company) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Relias LLC, is a Continuing Professional Education (CPE) Accredited Provider with the Commission on Dietetic Registration (CDR). Continuing Professional Education Provider Accreditation does not constitute endorsement by CDR of a provider, program or materials. This is a level 2 course with suggested CDR learning codes of 8.1.2, 8.1.3,10.4.1, 10.4.2, 10.4.3, 10.4.4, 10.4.5 and performance indicators of 2010, 3070, 4090, 5100, 5300.
OnCourse Learning is also accredited by the Florida Council of Dietetics and Nutrition (provider # 50-1489).

Course Originally Released on: 10/14/2014
Date of Most Recent Review: 10/15/2019
Course Termination/Update Date: 10/15/2022

Unless stated above, the planners and authors of this course have declared no relevant conflicts of interest that relate to this educational activity. Relias LLC guarantees this educational activity is free from bias.

Please see CE Course Instructions to learn how to earn CE credit for this module.


For Florida professionals:

If this course is approved by the Florida Council of Dietetics and Nutrition, this course completion will be electronically reported to CE Broker as required per Florida Statute 456.025(7). Click here to view your CE Broker transcript and check the status of your CE requirements with a FREE 7-day CE Broker trial subscription. It may take up to 24 hours for the course to appear on your CE Broker transcript.

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Read more about the new license renewal process at and claim your free Basic Account in CE Broker to see what has already been reported for you.

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Price: $20.00
CE-PRO Price: $10.00