The Holy Trinity: A Drug Combination for Caution - JA0008057-0000-19-268-H05-P

The Holy Trinity: A Drug Combination for Caution

by Seema Z Kazmi, PharmD
(5.0 / 2 ratings )

This course is credentialed for:
Pharmacy (0.50 Contact Hr)

Price: $11.00
CE-PRO Price: $5.50


This continuing education course evaluates the drug combination known as the “The Holy Trinity,” which consists of an opioid, a benzodiazepine, and a muscle relaxant. The synergistic activity of these drugs may potentiate adverse events and even lead to death. In combination, these drugs can induce side effects such as drowsiness, confusion, tremors, increased seizure risk, and respiratory depression, leading to death. “The Holy Trinity” also has been shown to bring about euphoria in patients, thus creating a potential for drug abuse and misuse. Pharmacists are frontline professionals who can advise patients on such drug interactions, provide the most appropriate therapy, and deter misuse or abuse.


The goal of this course is to provide education on the drug combination known as “The Holy Trinity.” The learner will be able to identify the components of “The Holy Trinity” combination, evaluate the associated risks, and understand the impact on healthcare services utilization. Upon completion of this course, you will be able to:
  • Identify patients at risk for receiving a “Holy Trinity” prescription.
  • Describe the potential adverse effects and pharmacology behind the “The Holy Trinity”.
  • Recognize the impact of pharmacist intervention on “The Holy Trinity,” specifically prevention.
  • Evaluate a patient’s medication profile using the Prescription Drug Monitoring Program for agents in the “The Holy Trinity”.

Accreditation Information
The course is intended for pharmacists
Jointly Accredited Provider logoIn support of improving patient care, OnCourse Learning (a Relias LLC company) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
OnCourse Learning is also approved by the Florida Board of Pharmacy (provider # 50-1489).
Type of Activity: Knowledge
Hours dedicated to pharmacology: 0.5 contact hours
Initial Release Date: 10/23/2019; Planned Expiration Date: 12/31/2019

Course Originally Released on: 10/1/2019
Date of Most Recent Review: 10/1/2019
Course Termination/Update Date: 12/31/2019

Unless stated above, the planners and authors of this course have declared no relevant conflicts of interest that relate to this educational activity. Relias LLC guarantees this educational activity is free from bias.

Please see CE Course Instructions to learn how to earn CE credit for this module.


For Florida professionals:

This course completion will be electronically reported to CE Broker as required per Florida Statute 456.025(7). Click here to view your CE Broker transcript and check the status of your CE requirements with a FREE 7-day CE Broker trial subscription. It may take up to 24 hours for the course to appear on your CE Broker transcript.

It is now required that all CE is completed and reported to CE Broker before you renew your license. When you complete continuing education with us, OnCourse Learning will report your hours for you.

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Price: $11.00
CE-PRO Price: $5.50