Melatonin: Separating Fact from Fiction - CMEZ-PH168

Melatonin: Separating Fact from Fiction

by Steven S. Bhimji, MD, PhD and Dale Ames Kline, MS, RD, LD
(4.3 / 49 ratings )

This course is credentialed for:
Medicine (1.00 Credits)
Physician (1.00 Credits)

Price: $15.00
CE-PRO Price: $7.50


The most well-studied clinical use of melatonin is manipulation of the circadian clock to treat jet lag and as a sleep aid. Normal melatonin cycles are disrupted when a person is exposed to excessive light in the evening or too little light during the daytime. Shift work, traveling across multiple time zones and exposure to bright lights can disrupt melatonin cycles. Some people appear to synthesize low levels of melatonin, for which melatonin supplementation may be beneficial. Recent studies also suggest that melatonin may have antioxidant properties, influence immunity, exert neuroprotective effects and may have a beneficial effect on neurocognition in the elderly. The effects of melatonin on the cardiovascular system and anti-aging have been assessed, but the results remain disputable; for most other disorders, there is little or no evidence regarding the benefits of melatonin. The hormone is safe when consumed at low doses.


The goal of this melatonin continuing education program is to provide pharmacists, physicians, pharmacy technicians and RDNs with information about melatonin, its pathophysiology and use in treatment. After studying the information presented here, you will be able to:
  • Discuss the physiology, biochemistry and kinetics of melatonin
  • Describe the mode of action of melatonin and its use for jet lag and insomnia and other conditions, including dose and treatment duration
  • List adverse effects, contraindications and interactions (with food and medications) of melatonin

Approval Information
This course is intended for an interprofessional audience, including pharmacists, pharmacy technicians, physicians and dietitians.
Physicians: Take this version of the course to ensure you receive appropriate credit.
For the version accredited or approved for another profession, go to your specific profession at or If you have a CE Direct login ID and password (generally provided by your employer), please log in as you normally would at and search for this topic title.
Jointly Accredited Provider logoIn support of improving patient care, OnCourse Learning (a Relias LLC company) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
OnCourse Learning is also approved by the Florida Board of Medicine and the Florida Board of Osteopathic Medicine (provider # FBN 50-1489).
Physician Continuing Education Credit
OnCourse Learning designates this enduring activity for a maximum of 1.0 AMA PRA category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Physician Assistant Continuing Education Credit
American Academy of Physician Assistants (AAPA) accepts certificates of participation for educational activities certified for AMA PRA Category 1 CreditTM from organizations accredited by ACCME or a recognized state medical society. Physician assistants may receive a maximum of 1.0 hour of Category I credit for completing this program.
There is no commercial support provided for this online educational activity.

Course Originally Released on: 10/14/2014
Date of Most Recent Review: 10/14/2014
Course Termination/Update Date: 10/14/2017

Unless stated above, the planners and authors of this course have declared no relevant conflicts of interest that relate to this educational activity. Relias LLC guarantees this educational activity is free from bias.

Please see CE Course Instructions to learn how to earn CE credit for this module.


For Florida professionals:

This course completion will be electronically reported to CE Broker as required per Florida Statute 456.025(7). Click here to view your CE Broker transcript and check the status of your CE requirements with a FREE 7-day CE Broker trial subscription. It may take up to 24 hours for the course to appear on your CE Broker transcript.

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Reports to CE Broker

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Annie P - San Diego, CA  ·  Jul 30, 2019
Wow. I did not realize all that Melatonin can be used for.
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Lambert H - fontana, CA  ·  Jul 01, 2019
content was well presented
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Hilary M - Bellingham, WA  ·  Mar 01, 2019
Great info, enjoyed reading
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KELLY S - Brookhaven, PA  ·  Aug 30, 2018
I learned a great deal about melatonin I did not have prior knowledge of
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Frederick V - Philadelphia, PA  ·  Aug 07, 2018
Not a very useful course
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Price: $15.00
CE-PRO Price: $7.50